The Journal of Arthroplasty
Volume 18, Issue 3 , Pages 352-360, April 2003

The application potential of sintered β-dicalcium pyrophosphate in total joint arthroplasty☆☆☆★

  • Jui-Sheng Sun, MD, PhD

      Affiliations

    • Department of Biomedical Engineering
    • Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei
    • ,
  • Yang-Hwei Tsuang, MD, PhD

      Affiliations

    • Department of Orthopedic Surgery, China Medical College Hospital, Taichung
    • ,
  • Feng-Huei Lin, PhD

      Affiliations

    • Department of Biomedical Engineering
    • Institutes of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ROC
    • ,
  • Li-Ting Chen, BS

      Affiliations

    • Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei
    • ,
  • Yi-Shiong Hang, MD

      Affiliations

    • Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei
    • ,
  • Hwa-Chang Liu, MD, PhD

      Affiliations

    • Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei

Received 28 February 2000; accepted 8 October 2002.

Abstract 

An in vitro bone cell culture model was used to evaluate the potential application of sintered β-dicalcium pyrophosphate (SDCP) in arthroplasty surgery. Primary osteoclasts and osteoblasts were cocultured with different sizes of SDCP particles. The changes in cell counts and the synthesis and secretion of alkaline phosphatase, acid phosphatase, and prostaglandin E2 in response to the SDCP particles were monitored. When bone cells were cultured with SDCP particles smaller than 53 μm, both the osteoblast and osteoclast cell counts decreased significantly. When the SDCP particles were larger than 177 μm, although the osteoblast population increased significantly, the osteoclast population decreased significantly. Simultaneously, the titer of prostaglandin E2 in the medium and the cytoplasmic prostaglandin E2 increased significantly. We concluded that SDCP is a potentially useful bioceramic for the prevention of osteoclast-mediated periprosthetic osteolysis. © 2003 Elsevier Inc. All rights reserved.

Keywords:  sintered β-dicalcium pyrophosphate, particle size, osteoclasts, osteoblasts, arthroplasty

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☆ Funds were received from the National Science Council, ROC, in support of the research material described in this study.

☆☆ Reprint requests: Feng-Huei Lin, PhD, Institute of Biomedical Engineering, National Taiwan University, No 1, Jen-Ai Road, Taipei, Taiwan, ROC.

★ 0883-5403/03/1803-0018$30.00/0

PII: S0883-5403(02)06255-1

doi:10.1054/arth.2003.50054

The Journal of Arthroplasty
Volume 18, Issue 3 , Pages 352-360, April 2003

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