The Journal of Arthroplasty
Volume 23, Issue 1 , Pages 145-150 , January 2008

Treatment of Infected Hip Arthroplasty With Antibiotic-Impregnated Calcium Hydroxyapatite

Received 27 February 2006 ,Accepted 21 September 2006.

References 

  1. Goulet JA, Pelicci PM, Brause BD, et al. Prolonged suppression of infection in total hip arthroplasty. J Arthroplasty. 1988;3:97
  2. Tsukayama DT, Wicklund B, Gustilo RB. Suppressive antibiotic therapy in chronic prosthetic joint infections. Orthopedics. 1991;14:841
  3. Crockarell JR, Hanssen AD, Osmon DR, et al. Treatment of infection with debridement and retention of the components following hip arthroplasty. J Bone Joint Surg Am. 1998;80:1306
  4. Tattevin P, Cremieux AC, Pottier P, et al. Prosthetic joint infection: when can prosthesis salvage be considered?. Clin Infect Dis. 1999;29:292
  5. Grauer JD, Amstutz HC, O'Carroll PF, et al. Resection arthroplasty of the hip. J Bone Joint Surg Am. 1989;71:669
  6. Castellanos J, Flores X, Llusa M, et al. The girdlestone pseudarthrosis in the treatment of infected hip replacements. Int Orthop. 1998;22:178
  7. Kostuik J, Alexander D. Arthrodesis for failed arthroplasty of the hip. Clin Orthop. 1984;188:173
  8. Durbhakula SM, Czajka J, Fuchs MD, et al. Spacer endoprosthesis for the treatment of infected total hip arthroplasty. J Arthroplasty. 2004;19:760
  9. Hofmann AA, Goldberg TD, Tanner AM, et al. Ten-year experience using an articulating antibiotic cement hip spacer for the treatment of chronically infected total hip. J Arthroplasty. 2005;20:874
  10. Fenelon GC, von Foerster G, Engelbrecht E. Disarticulation of the hip as a result of failed arthroplasty. J Bone Joint Surg Am. 1980;62:441
  11. Brien WW, Salvati EA, Klein R, et al. Antibiotic impregnated bone cement in total hip arthroplasty. An in vivo comparison of the elution properties of tobramycin and vancomycin. Clin Orthop. 1993;296:242
  12. Kendall RW, Duncan CP, Smith JA, et al. Persistence of bacteria on antibiotic loaded acrylic depots. A reason for caution. Clin Orthop. 1996;329:273
  13. Klemm KW. Antibiotic bead chains. Clin Orthop. 1993;295:63
  14. Kirkpatrick DK, Von Fraunhofer JA, Trachtenberg LS, et al. In vitro characteristics of tobramycin-PMMA beads: comprehensive strength and leaching. Orthopedics. 1985;8:1130
  15. Mader JT, Shirtliff ME, Bergquist SC, et al. Anitimicrobial treatment of chronic osteomyelitis. Clin Orthop. 1999;360:47
  16. Murray WR. Use of antibiotic-containing bone cement. Clin Orthop. 1984;190:89
  17. Cerretani D, Giorgi G, Fornara P, et al. The in vitro elution characteristics of vancomycin combined with imipenem-cilastatin in acrylic bone-cements. J Arthroplasty. 2002;17:619
  18. Pittp RP, Spika IA. Antibiotic-loaded bone cement spacers in two-stage management of infected total knee arthroplasty. Int Orthop. 2004;18:129
  19. Shinto Y, Uchida A, Korkusuz F, et al. Calcium hydroxyapatite ceramic used as a delivery system for antibiotics. J Bone Joint Surg Br. 1992;74:600
  20. Uchida A, Shinto Y, Araki N, et al. Slow release of anticancer drugs from porous calcium hydroxyapatite ceramic. J Orthop Res. 1992;10:440
  21. Uchida A, Araki N, Shinto Y, et al. The use of calcium hydroxyapatite ceramic in bone tumor surgery. J Bone Joint Surg Br. 1990;72:298
  22. Uchida A, Nade SML, McCartney ER, et al. Bone ingrowth into three different porous ceramics implanted into the tibia of rats and rabbits. J Orthop Res. 1985;3:65
  23. Uchida A, Nade SML, McCartney ER, et al. The use of ceramics for bone replacement. A comparative study of three different porous ceramics. J Bone Joint Surg Br. 1984;66:269
  24. Yamashita Y, Uchida A, Yamakawa T, et al. Treatment of chronic osteomyelitis using calcium hydroxyapatite ceramic implants impregnated with antibiotic. Int Orthop. 1998;22:247
  25. Yamashita Y, Yamakawa T, Kato K, et al. Calcium hydroxyapatite ceramic implants impregnated with antibiotic for the treatment of chronic osteomyelitis. Bioceramics. 1997;10:91
  26. Lonner JH, Desai P, Dicesare PE, et al. The reliability of analysis of intraoperative frozen sections for identifying active infection during revision hip or knee arthroplasty. J Bone Joint Surg Am. 1996;78:1553
  27. DeLee JG, Charnley J. Radiological demarcation of cemented sockets in total hip replacement. Clin Orthop. 1976;121:20
  28. Engh CA, Massin P, Suthers KE. Roentgenographic assessment of the biologic fixation of porous-surfaced femoral components. Clin Orthop. 1990;257:107
  29. Baker AS, Greenham LW. Release of gentamicin from acrylic bone cement: elution and diffusion studies. J Bone Joint Surg Am. 1988;70:1551
  30. Blaha JD, Calhoun JH, Nelson CL, et al. Comparison of the clinical efficacy and tolerance of gentamicin PMMA beads on surgical wire versus combined and systemic therapy for osteomyelitis. Clin Orthop. 1993;295:8
  31. Buchholz HW, Elson RA, Heinert K. Antibiotic-loaded acrylic cement: current concepts. Clin Orthop. 1984;190:96
  32. Vaudaux PE, Zulian G, Huggler E, et al. Attachment of staphylococcus aureus to polemethylmethacrylate increases its resistance to phagocytosis in foreign body infection. Infect Immun. 1985;50:472
  33. Hsieh PH, Shih CH, Chang YH, et al. Treatment of deep infection of the hip associated with massive bone loss. J Bone Joint Surg Br. 2005;87:770
  34. Korkusuz F, Uchida A, Shinto Y, et al. Experimental implant-related osteomyelitis treated by antibiotic-calcium hydroxyapatite ceramic composites. J Bone Joint Surg Br. 1993;75:111
  35. Ger E, Dall D, Miles T, et al. Bone cement and antibiotics. S Afr Med J. 1977;51:276
  36. Masri BA, Duncan CP, Beauchamp CP. Long-term elution of antibiotics from bone-cement. An in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) system. J Arthroplasty. 1998;13:331
  37. Cherney DL, Amstutz HC. Total hip replacement in the previously septic hip. J Bone Joint Surg Am. 1983;65:1256
  38. Garvin KL, Evans BG, Salvati EA, et al. Palacos gentamicin for the treatment of deep periprosthetic hip infections. Clin Orthop. 1994;298:97
  39. Hope P, Kristinsson KG, Norman P, et al. Deep infection of cemented total hip arthroplasties caused by coagulase-negative staphylococci. J Bone Joint Surg Br. 1989;71:851
  40. Hunter GA. The results of reinsertion of a total hip prosthesis after sepsis. J Bone Joint Surg Br. 1979;61:422

 No benefits or funds were received in support of the study.

PII: S0883-5403(06)00695-4

doi: 10.1016/j.arth.2006.09.009

The Journal of Arthroplasty
Volume 23, Issue 1 , Pages 145-150 , January 2008