The Journal of Arthroplasty
Volume 24, Issue 7 , Pages 1015-1018, October 2009

Antibiotic Bone Cement and the Incidence of Deep Infection after Total Knee Arthroplasty

  • Rajiv Gandhi, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Rajiv Gandhi, MD, Toronto Western Hospital, East Wing 1-439, 399 Bathurst St, Toronto, ON, Canada M5T 2S8.
    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
    • ,
  • Fahad Razak, MD

      Affiliations

    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
    • Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    • ,
  • Rubini Pathy, MD

      Affiliations

    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
    • ,
  • J. Roderick Davey, MD

      Affiliations

    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
    • ,
  • Khalid Syed, MD

      Affiliations

    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
    • ,
  • Nizar N. Mahomed, MD, ScD

      Affiliations

    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada

Received 9 May 2008; accepted 23 August 2008. published online 26 September 2008.

Abstract 

We asked if the use of antibiotic-laden bone cement (ALBC) decreased the deep infection rate after primary total knee arthroplasty as compared to plain bone cement. We surveyed 1625 consecutive patients for relevant covariates. Joint pain and function were assessed at baseline and at 1 year of follow-up with the Western Ontario McMaster University Osteoarthritis Index scores. The incidence of deep infection at 1-year follow-up was recorded. There were no differences in baseline covariates between groups (P > .05). We found a deep infection rate of 2.2% in the ALBC group and 3.1% in the plain bone cement group (P = .27). Adjusted analysis showed that ALBC was not predictive of a lower infection rate at 1 year (P = .84). Antibiotic-laden bone cement did not reduce the incidence of deep infection following primary total knee arthroplasty at 1-year follow-up.

Keywords: knee arthroplasty, infection, antibiotic cement, prophylaxis

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 No benefits or funds were received in support of this study.

PII: S0883-5403(08)00694-3

doi:10.1016/j.arth.2008.08.004

The Journal of Arthroplasty
Volume 24, Issue 7 , Pages 1015-1018, October 2009

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