The Journal of Arthroplasty
Volume 24, Issue 7 , Pages 1015-1018 , October 2009

Antibiotic Bone Cement and the Incidence of Deep Infection after Total Knee Arthroplasty

  • Rajiv Gandhi, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Rajiv Gandhi, MD, Toronto Western Hospital, East Wing 1-439, 399 Bathurst St, Toronto, ON, Canada M5T 2S8.
    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
    • ,
  • Fahad Razak, MD

      Affiliations

    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
    • Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    • ,
  • Rubini Pathy, MD

      Affiliations

    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
    • ,
  • J. Roderick Davey, MD

      Affiliations

    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
    • ,
  • Khalid Syed, MD

      Affiliations

    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada
    • ,
  • Nizar N. Mahomed, MD, ScD

      Affiliations

    • Division of Orthopedic Surgery, University of Toronto, Toronto, ON, Canada

Received 9 May 2008 ,Accepted 23 August 2008.

References 

  1. Rorabeck CH. Session IV: salvage of the infected total knee replacement. Clin Orthop Rel Res. 2002;404:113
  2. Bourne RB. Prophylactic use of antibiotic bone cement: an emerging standard—in the affirmative. J Arthroplasty. 2004;19(Suppl 4):69
  3. Peersman G, Laskin R, Davis J, et al. Infection in total knee replacement: a retrospective review of 6489 total knee replacements. Clin Orthop Rel Res. 2001;392:15
  4. Meding JB, Keating EM, Ritter MA, et al. Long-term followup of posterior-cruciate-retaining TKR in patients with rheumatoid arthritis. Clin Orthop Relat Res. 2004;428:146
  5. Sharma S, Nicol F, Hullin MG, et al. Long-term results of the uncemented low contact stress total knee replacement in patients with rheumatoid arthritis. J Bone Joint Surg Br. 2005;87:1077
  6. Amenabar PP, Carrion M, Apablaza D, et al. Total knee arthroplasty in patients with rheumatoid arthritis. Rev Med Chile. 2004;132:337;[Spanish]
  7. Kurtz S, Lau E, Schmier J, et al. Nationwide infection burden in revision hip and knee arthroplasty. Trans Orthop Res Soc. 2006;31:179
  8. Kurtz S, Ong KL, Schmier J, et al. Future clinical and economic impact of revision total hip and knee arthroplasty. J Bone Joint Surg Am. 2007;89:144
  9. Heck D, Rosenberg A, Schink-Ascani M, et al. Use of antibiotic impregnated cement during hip and knee arthroplasty in the United States. J Arthroplasty. 1995;10:470
  10. Sculco TP. The economic impact of infected total joint arthroplasty. Instr Course Lect. 1993;42:349
  11. Chiu FY, Lin CF, Chen CM, et al. Cefuroxime-impregnated cement at primary total knee arthroplasty in diabetes mellitus. J Bone Joint Surg Br. 2001;83-B:691
  12. Chiu FY, Chen CM, Lin CF, et al. Cefuroxime-impregnated cement in primary total knee arthroplasty: a prospective, randomized study of three hundred and forty knees. J Bone Joint Surg Br. 2002;84:759
  13. Hanssen AD. Prophylactic use of antibiotic bone cement: an emerging standard—in opposition. J Arthroplasty. 2004;19(S4):73
  14. Horan TC, Gaynes RP, Martone WJ, et al. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol. 1992;13:606
  15. Charlson M, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373
  16. Bellamy N, Buchanan WW, Goldsmith CH, et al. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;5:1833
  17. Jiranek WA, Hanssen AD, Greenwald AS. Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement. J Bone Joint Surg Am. 2006;88:2487
  18. Yang K, Yeo SJ, Lee BP, et al. Total knee arthroplasty in diabetic patients: a study of 109 consecutive cases. J Arthroplasty. 2001;16:102
  19. England SP, Stern SH, Insall JN, et al. Total knee arthroplasty in diabetes mellitus. Clin Orthop Relat Res. 1990;260:130
  20. Meding JB, Reddleman K, Keating ME, et al. Total knee replacement in patients with diabetes mellitus. Clin Orthop Relat Res. 2003;416:208
  21. Blom AW, Brown J, Taylor AH, et al. Infection after total knee arthroplasty. J Bone Joint Surg Br. 2004;86:688
  22. Arciola CR, Campoccia D, Montanaro L. Effects on antibiotic resistance of Staphylococcus epidermidis following adhesion to polymethylmethacrylate and to silicone surfaces. Biomaterials. 2002;6:1495
  23. Joseph TN, Chen AL, Di Cesare PE. Use of antibiotic impregnated cement in total joint arthroplasty. J Am Acad Orthop Surg. 2003;11:38
  24. Davies JP, Harris WH. Effect of hand mixing tobramycin on the fatigue strength of Simplex P. J Biomed Mater Res. 1991;25:1409
  25. Masari BA, Duncan CP, Beauchamp CP. Long-term elution of antibiotics from bone cement: an in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) system. J Arthroplasty. 1998;13:331
  26. Adelberth G, Nilsson KG, Karrholm J, et al. Fixation of the tibial component using CMW-1 or Palacos bone cement with gentamicin: similar outcome in a randomized radiostereometric study of 51 total knee arthroplasties. Acta Orthop Scand. 2002;73:531
  27. Davies JP, O'Connor DO, Burke DW, et al. Influence of antibiotic impregnation on the fatigue life of Simplex P and Palacos R acrylic bone cements, with and without centrifugation. J Biomed Mater Res. 1989;23:379

 No benefits or funds were received in support of this study.

PII: S0883-5403(08)00694-3

doi: 10.1016/j.arth.2008.08.004

The Journal of Arthroplasty
Volume 24, Issue 7 , Pages 1015-1018 , October 2009

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