The Journal of Arthroplasty
Volume 25, Issue 3 , Pages 416-419, April 2010

Asian Ethnicity and the Prevalence of Metabolic Syndrome in the Osteoarthritic Total Knee Arthroplasty Population

  • Rajiv Gandhi, MD, SM, FRCSC

      Affiliations

    • Division of Orthopedic Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    • Corresponding Author InformationReprint requests: Rajiv Gandhi, MD, SM, FRCSC, Toronto Western Hospital, East Wing 1-439, 399 Bathurst St, Toronto, ON, Canada M5T 2S8.
    • ,
  • Fahad Razak, MSc

      Affiliations

    • Division of Orthopedic Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    • Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Peggy Tso, BHSc

      Affiliations

    • Division of Orthopedic Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    • ,
  • J. Roderick Davey, MD, FRCSC

      Affiliations

    • Division of Orthopedic Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Nizar N. Mahomed, MD, ScD, FRCSC

      Affiliations

    • Division of Orthopedic Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada

Received 7 July 2008; accepted 4 February 2009. published online 12 March 2009.

Abstract 

Metabolic syndrome (MS) is a known risk factor for the development of osteoarthritis (OA). We asked whether the prevalence of MS varies across ethnicity among patients who undergo total knee arthroplasty for end-stage OA. In our population of 1460 patients undergoing primary knee arthroplasty, MS was defined as body mass index greater than 30 kg/m2, diabetes, hypertension, and hypercholesterolemia. Among the 1334 white patients, 114 (8.5%) had MS as compared with 3 of 36 (8.3%) blacks and 18 of 90 (20%) Asians (P = .006) Adjusted analysis showed that those of Asian ethnicity had a 2.0 (95% confidence interval, 1.1-3.8; P = .03) times greater odds of MS as compared with those of other ethnicity. Metabolic syndrome is a risk factor for OA, and Asians demonstrate a greater prevalence of MS as compared with whites and blacks in this population.

Keywords: metabolic syndrome, ethnicity, knee osteoarthritis, Asians

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 No benefits or funds were received in support of the study.

PII: S0883-5403(09)00052-7

doi:10.1016/j.arth.2009.02.005

The Journal of Arthroplasty
Volume 25, Issue 3 , Pages 416-419, April 2010

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