The Journal of Arthroplasty
Volume 25, Issue 6 , Pages 990-997, September 2010

Compression Strength and Porosity of Single-Antibiotic Cement Vacuum-Mixed With Vancomycin

Department of Orthopedic Surgery, The University of Kansas Medical Center, Kansas City, Kansas

Received 30 December 2008; accepted 17 June 2009. published online 13 August 2009.

Abstract 

We evaluated the ultimate compression strength (UCS), porosity, and fracture surface roughness of 2 commercially available single-antibiotic bone cements vacuum-mixed with additional amounts of vancomycin (2, 4, 6, and 8 g). At least 8 g could be added to Palacos R + 0.5 g gentamicin (UCS = 75.04 ± 6.64 MPa) and no more than 6 g to Simplex P + 1 g tobramycin (UCS = 78.93 ± 4.98 MPa) to maintain a UCS above the International Organization for Standardization minimum standard (70 MPa). Increasing vancomycin concentration correlated with a decrease in porosity but showed a trend towards greater fracture surface roughness.

Keywords: Bone cement, antibiotics, vacuum-mixing, porosity, surface roughness, compression strength

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 Partial support provided by the Marc A. and Elinor J. Asher Orthopedic Research Endowment.

 No benefits or funds were received in support of the study.

PII: S0883-5403(09)00254-X

doi:10.1016/j.arth.2009.06.027

The Journal of Arthroplasty
Volume 25, Issue 6 , Pages 990-997, September 2010

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