The Journal of Arthroplasty
Volume 26, Issue 6, Supplement , Pages 99-103.e1, September 2011

Molecular Markers for Diagnosis of Periprosthetic Joint Infection

  • Christina L. Jacovides, BS
    • ,
  • Javad Parvizi, MD, FRCS

      Affiliations

    • Corresponding Author InformationReprints requests: Javad Parvizi, MD, FRCS, Rothman Institute of Orthopedics at Thomas Jefferson University Hospital, 925 Chestnut Street, Philadelphia, PA 19107.
    • Javad Parvizi: Consultant for Stryker Orthopaedics and has intellectual properties on SmarTech.
    • ,
  • Bahar Adeli, BA
    • ,
  • Kwang Am Jung, MD

Received 20 December 2010; accepted 11 March 2011. published online 16 May 2011.

Abstract 

Despite a battery of tests available for diagnosing periprosthetic joint infection, as yet, no gold standard has been identified. Our purpose was to measure inflammatory proteins in synovial fluid from patients undergoing revision arthroplasty for septic or aseptic failure. We analyzed 74 synovial fluid samples: 31 infected and 43 uninfected, based on clinical and laboratory criteria. Proteomics analysis and receiver operating characteristic curve analyses were conducted on 46 inflammatory proteins for each sample. Of 46 proteins, 5 (interleukin 6, interleukin 8, α2-macroglobulin, C-reactive protein, and vascular endothelial growth factor) had an area under the curve greater than 0.90. This prospective study has demonstrated promising results for the use of molecular markers in diagnosis of periprosthetic joint infection. Future studies will focus on designing assays with these proteins in mind.

Keywords: molecular markers, periprosthetic joint infection, synovial fluid, revision total knee arthroplasty, revision total hip arthroplasty

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 Supplementary material available at www.arthroplastyjournal.org.

 The Conflict of Interest statement associated with this article can be found at doi:10.1016/j.arth.2011.03.025.

PII: S0883-5403(11)00124-0

doi:10.1016/j.arth.2011.03.025

The Journal of Arthroplasty
Volume 26, Issue 6, Supplement , Pages 99-103.e1, September 2011

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