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Comparison of Arthroplasty Trial Publications After Registration in ClinicalTrials.gov

  • Holly N. Smith

      Affiliations

    • Toronto Western Hospital EW 1-433, Toronto, Ontario
    • ,
  • Mohit Bhandari, MSc, MD

      Affiliations

    • Hamilton General Hospital, Hamilton, Ontario
    • ,
  • Nizar N. Mahomed, MD, ScD

      Affiliations

    • Toronto Western Hospital EW 1-435, Toronto, Ontario
    • ,
  • Meryam Jan

      Affiliations

    • Toronto Western Hospital EW 1-433, Toronto, Ontario
    • ,
  • Rajiv Gandhi, MS, MD

      Affiliations

    • Toronto Western Hospital EW 1-439, Toronto, Ontario
    • Corresponding Author InformationReprint requests: Rajiv Gandhi, MS, MD, Toronto Western Hospital EW 1-439, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8.

Received 8 February 2011; accepted 10 November 2011. published online 09 January 2012.
Corrected Proof

Abstract 

In 2005, the International Committee of Medical Journal Editors established a mandatory trial registration before study enrollment for publication in member journals. Our primary objective was to evaluate the publication rates of arthroplasty trials registered with ClinicalTrials.gov (CTG). We further aimed to examine the consistency of registration summaries with that of final publications. We searched CTG for all trials related to joint arthroplasty and conducted a thorough search for publications resulting from registered closed trials. Of 101 closed and completed trials, we found 23 publications, for an overall publication rate of 22.8%. Registration of arthroplasty trials in CTG does not consistently result in publication or disclosure of results. In addition, changes are frequently made to the final presentation of the data that are not reflected in the trial registry.

Keywords: Trial registration, Clinicaltrials.gov, Arthroplasty

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 The Conflict of Interest statement associated with this article can be found at doi:10.1016/j.arth.2011.11.005.

 Source of funding: There was no external funding source involved in this study.

PII: S0883-5403(11)00629-2

doi:10.1016/j.arth.2011.11.005

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