This study evaluated the effect of periarticular pain cocktail, platelet-rich plasma, or fibrin sealant injections on blood loss, transfusion rate, and hospital costs after total knee arthroplasty. A retrospective review of 400 patients undergoing primary total knee arthroplasty with one of the different periarticular treatments as stated above was performed. Postoperative blood loss, hemoglobin levels, allogenic blood transfusion rates, and per-case hospital injection cost were reported. Although platelet-rich plasma and fibrin sealant decreased blood loss compared with the control group (P < .001), there was no significant difference in blood loss in the pain-cocktail group or in postoperative hemoglobin levels or transfusion rates between all groups. Significant efficacy and cost-effectiveness for these modalities could not be identified and have, therefore, been discontinued at our practice. Level of evidence: level III.
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Published online: April 23, 2012
Accepted: February 23, 2012
Received: September 30, 2011
The Conflict of Interest statement associated with this article can be found at doi:10.1016/j.arth.2012.02.018.
Source of funding: The Foundation for Orthopaedic Research and Education received an educational grant from the Tampa General Hospital in support of this project.
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.