Abstract
Functional exercise after total knee arthroplasty (TKA) is necessary. However, it
may be a difficult and painful process for the patient. Desirable methods of relieving
the patient's pain are worth exploring. Oral supplement of adenosine triphosphate
(ATP) is a potential option. In the present study, we decide to investigate whether
short-term administration of ATP benefits patients undergoing TKA. A total of 244
subjects were randomized to receive 120 mg ATP or placebo each day for 4 weeks. Significant differences in quadriceps strength, pain scores at postoperative
days 7, 14, 21, and 28 and total opioid consumption were detected. It follows that
oral supplement of ATP could benefit patients recovering from TKA.
Keywords
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References
- Total knee replacement: the joint of the decade. A successful operation, for which there's a large unmet need.BMJ. 2000; 320 ([Mar 25]): 820
- Effectiveness of electric stimulation of the vastus medialis muscle in the rehabilitation of patients after total knee arthroplasty.Arch Phys Med Rehabil. 2003; 84 ([Dec]): 1850
- Comparing conventional physical therapy rehabilitation with neuromuscular electrical stimulation after TKA.Orthopedics. 2013; 36 ([Mar]): e319
- Electrical muscle stimulation for osteoarthritis of the knee biological basis and systematic review.N Z J Physiother. 2000; 28
- What is the efficiency of ATP signaling from erythrocytes to regulate distribution of O(2) supply within the microvasculature?.Microcirculation. 2012; 19: 440
- Effects of oral ATP supplementation on anaerobic power and muscular strength.Med Sci Sports Exerc. 2004; 36: 983
- Effects of ATP-induced leg vasodilation on VO2 peak and leg O2 extraction during maximal exercise in humans.Am J Physiol Regul Integr Comp Physiol. 2006; 291: R447
- Adenosine receptors: pharmacology, structure-activity relationship, and therapeutic potential.Med Chem. 1992; 35: 408
- A randomized, double-blind, placebo controlled triphosphate in study of oral adenosine subacute low back pain.J Rheumatol. 2005; 32: 1114
- Measuring the contribution of pharmacological treatment to advice to stay active in patients with subacute low-back pain: a randomised controlled trial.Pharmacoepidemiol Drug Saf. 2005; 14: 861
- Clinical application of adenosine and ATP for pain control.J Anesth. 2005; 19: 225
- ATP and pain.Pain Pract. 2002; 2 ([Dec]): 289
Article info
Publication history
Published online: March 31, 2014
Accepted:
March 24,
2014
Received:
September 24,
2013
Footnotes
The Conflict of Interest statement associated with this article can be found at http://dx.doi.org/10.1016/j.arth.2014.03.025.
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
